Advancing Patient Welfare
Are you interested to tackle clinically-related questions with the aim to more directly help improve the management of patients? Are you interested to help patients by working on unique solutions? Do you prefer working with people or patient samples? If you have answered ‘’yes’’ to these rhetorical questions then this study is the perfect match to satisfy your love for people and the burning need to find solutions to improve human health more speedily!
What is it about?
This is an ongoing clinical study that investigates the links between HIV-AIDS and the onset of cardio-metabolic diseases. Due to the successful anti-retroviral therapy roll-out over the last decade, HIV-AIDS is now managed as a chronic condition meaning such individuals display near-normal lifespans. In parallel, however, there is a substantial increase in the onset of cardio-metabolic complications in HIV-positive individuals. This is a serious health problem that is not well understood and therefore require further exploration to unravel the underlying mechanisms driving this process. To help advance this worthy cause, the CMRG launched the ‘’Cape Winelands HAART to HEART Study’’ a few years ago in Worcester (Western Cape, South Africa) to investigate the contributions of anti-retroviral treatments and HIV-related inflammation as putative contributors to such pathologies. Our initial investigations revealed immune activation and coagulation in HIV-positive patients and we have built up an excellent biobank of plasma and serum samples for future studies. If successfully completed, our studies should make a significant contribution towards understanding the etiology of HIV-related cardio-metabolic diseases and also eventually aid in the clinical management of HIV-positive patients.
Blood sample collection at the Worcester Community Day Center (South Africa), biobank sample management, evaluation of immune and coagulation markers by flow cytometry, ELISAs, lipid analyses, metabolic assessments, mitochondrial energy production, oxidative stress markers.
Prof. Monte Willis, University of North Carolina, Chapel Hill, NC
Prof. Jean Van Den Elsen, University of Bath, UK